A reliable, cost effective and rapid diagnostic test, which can be performed in any routine laboratory, could be of help in the diagnosis of TBM. Heterozygotes cannot be identified by this test. This study demonstrated that ADA activity in the CSF of TBM patients, using a cut-off value 11.39 U/L/min, can be useful for the early differential diagnosis of TBM. Feedback. Feedback . One of the rea-sons for this is the different cut-offs used. This test was developed and its performance characteristics determined by ARUP Laboratories. In the monomer form, the enzyme is a polypeptide chain, folded into eight strands of parallel α/β barrels, which surround a central deep pocket that is the active site. In the present study we measured the adenosine deaminase (ADA) activity in cerebrospinal fluid (CSF) of TBM and non-TBM patients. Background: Tuberculous meningitis (TBM) is often under and over diagnosed, thereby making the ancillary diagnostic tests important for establishing the diagnosis of TBM.The objective of this study was to evaluate cerebrospinal fluid adenosine deaminase (CSF-ADA) as an ancillary test for the diagnosis of TBM, and further, its correlation with adverse neurological outcome in these patients. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Adenosine Deaminase, CSF: 35703-8 * Component test codes cannot be used to order tests. ... Other names that describe the test. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Adenosine Deaminase, CSF - An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. CSF is formed and secreted by the choroid plexus, a special tissue that has many blood vessels and that lines the small cavities or chambers (ventricles) in the brain. ADA; Adenosine Deaminase in CSF. Page 16 ©Asian Journal of Biomedical and Pharmaceutical Sciences, 2015. conducted to find out the usefulness of these two tests, CSF-ADA & CSF-CRP for the rapid diagnosis & dif-ferentiation of bacterial, tubercular & viral meningitis. ADA exists in both small form (as a monomer) and large form (as a dimer-complex). weeks, clinicians rely heavily on CSF ADA as a rule-in test, because of its fast turn-around time. Prompt diagnosis and treatment are essential. As a catalyzing enzyme that converts adenosine to inosine [5] , ADA's physiologic function is related to the proliferation, maturation and … Amol R. Shinde, et al: Asian Journal of Biomedical and Pharmaceutical Sciences, 5(44), 2015, 15-18. There is a need for a simple and fast laboratory test to differentiate TBM from other causes. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map. Structure. ADA deficiency is the cause of 20-30 percent of SCID cases. A CSF analysis is a group of tests that evaluate substances in CSF in order to diagnose conditions affecting the brain and spinal cord (central nervous system). The ADA test gave a sensitivity of 82% and a specificity of 83% for infectious TBM when this cut-off value was used. CSF ADA activity should be interpreted with caution in light of the patient's condition since there is a wide range of CSF ADA activity in TBM. Web: mayocliniclabs.com: Email: mcl@mayo.edu: Telephone: 800-533-1710: International: +1 855-379-3115: Values are valid only on day of printing. However, as indicated in Table 1, the sensitivity and specificity of CSF ADA uti-lised in the diagnostic work-up of suspected TBM patients cited in the literature vary considerably. 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